VDR is a gene which encodes for a protein that acts as a receptor for vitamin D that regulates bone formation and calcium absorption. A variant of the gene (rs2228570 FokI polymorphism) is associated with a reduced bone mineral density among white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the temporal and reciprocal pattern of off- and on- occupancy of the VDRE by two components, and is modulated by chromosomal locations and by binding preferences for certain hormones. Microarray studies of human cells show that more than 100 genes contain a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository for data and documents that are relevant to legal, business transactions or other proceedings that have restrictions on viewing or downloading. It utilizes central computers and an extranet, which is a restricted-access Internet connection, to allow users to access the internet at specific times.
Companies and investment banks that are involved in mergers and acquisitions are the most common users of VDRs. VDR. They require a secure platform to share information with investors or buyers in a transparent way, and the process of due diligence can require massive quantities of data. Life science companies also use VDRs to store everything from clinical trial results to HIPAA documentation.